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KMID : 0882420110810010073
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Korean Journal of Medicine
2011 Volume.81 No. 1 p.73 ~ p.81
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The Association between Albuminuria and Peripheral Arterial Disease in Patients with Type 2 Diabetes Mellitus
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Park Seong-Hwan
Chung Jin-Ook
Cho Dong-Hyeok
Chung Dong-Jin
Chung Min-Young
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Abstract
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Background/Aims: Albuminuria is an early indicator of renal damage in type 2 diabetes mellitus, and has been recognized as a risk factor for peripheral arterial disease (PAD). The aim of this study was to assess the association between albuminuria and PAD in Korean type 2 diabetes patients.
Methods: Our retrospective study included 390 consecutive patients with type 2 diabetes mellitus. The ankle-brachial index (ABI) and toe-brachial index (TBI) were used to assess PAD. The urinary albumin-creatinine excretion ratio (UAE) was evaluated by determining the albumin/creatinine ratio (ACR) in the first voided morning urine sample.
Results: Duration of diabetes, serum creatinine levels, and UAE were significantly higher in patients with low ABI scores (< 0.9) than in those with normal ABI scores (≥ 0.9). Age, duration of diabetes, and UAE were significantly higher in patients with low TBI scores (< 0.6) than in those with normal TBI scores (≥ 0.6). Albuminuria was independently associated with low ABI (OR = 1.980, 95% CI = 1.001-3.918). It was also independently associated with low TBI and normal ABI (OR = 3.149, 95% CI = 1.260-7.871).
Conclusions : The results of this study suggest that albuminuria may be associated with PAD, including in arteries distal to the ankle joint.
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KEYWORD
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Diabetes mellitus, Albuminuria, Peripheral vascular disease
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